Prof. Wong Jiemin's Team Find the Vital Role of UHRF1 in Epigenetic Inheritance

2013-03-26


Prof. Wong Jiemin and a visiting scholar at the laboratory.

 

Epigenetic inheritance of DNA methylation in mammals requires a multifunctional protein UHRF1, which is believed to recruit DNMT1 to DNA replication forks through a unique hemi-methylated CpG-binding activity. Prof. Wong Jiemin and his research team found the functions of UHRF1 in epigenetic inheritance of DNA methylation and published their findings in Nature Communications, a weekly peer-reviewed scientific journal published by the Nature Publishing Group, on March 5. 

 

 
Dr. Li Pishun makes cell culture at the laboratory.

 

 With deep going experiments, researchers of Prof. Wong Jiemin's team demonstrate that UHRF1 can target DNMT1 for DNA maintenance methylation through binding either H3K9me2/3 or hemi-methylated CpG, and that the presence of both binding activities ensures high fidelity DNA maintenance methylation. In addition, they also indicate that UHRF1 mediates cross-talk between H3K9 methylation and DNA methylation at the level of DNA methylation maintenance. 

 

 

Reseachers work at the cell laboratory.

 

The findings were completed by Prof. Wong Jiemin and his team members Liu Xiaoli, Gao Qinqin and Li Pishun.  Prof. Wong, an expert of microbiology and molecular genetics, has focused his research on the molecular mechanism of gene regulation by nuclear hormone receptors (NRs) and the mechanism of epigenetic for years and has made a lot of progress on the functional analysis of the coregulators of NRs. He has published more than 70 research papers on top journals including Cell, Nature and Science. And his papers have been cited by others for more than 2000 times. In 2001, he got the Richard E. Weitzman Memorial Award from Endocrine Society because of his achievement in research.  

 

Written by: Liu Jinyu

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华东师范大学
East China Normal University