Zhu Shujia, a 2009 Ph.D candidate under the joint training program of ECNU and Ecole Normale Supérieure, published her research paper as the first author in Nature Structural & Molecular Biology, a peer-reviewed academic journal publishing research articles, reviews, news and commentaries in structural biology and molecular biology, on March 3.
The research results contained in Zhu’s paper titled Allosteric Signaling and Dynamics of the Clamshell-like NMDA Receptor GluN1 N-terminal Domain was completed by Ecole Normale Supérieure and ECNU-Paris Institute of Physical and Chemical Biology. Zhu was in charge of the theoretical design, experimental operation, data analysis and paper writing. Zhu’s supervisors include Prof. Lin Longnian and Prof. Mei Bing of Key Laboratory of Brain Functional Genomics, and Pierre Paoletti of Ecole Normale Superieure.
N-methyl-D-aspartate (NMDA) receptor is an important kind of excitatory glutamic acid receptor in the central nervous system of mammals, which plays a crucial biological role in the development of the nervous system and in the formation of neural circuit. In the newly published paper, Zhu and her colleagues first reported the regulatory mechanism of the N terminal domain of NMDA receptor -GluN1 subunit on the activity of ion channels and pharmacological properties. Their research found that the N terminal domain of NMDA receptor -GluN1 subunit is neither static nor silent in function.
The Sino-French Joint Postgraduate Training Program has cultivated a large number of outstanding students since its beginning in 2002. Among the 289 postgraduate students enrolled in the program, 97 of them have been chosen for the Sino-French Joint Ph.D Training Program, and 52 of them have passed the thesis defense for Ph.D degree successfully. Statistics show graduates of the Sino-French Joint Ph.D Training Program have published nearly 180 high quality papers in academic journals at home and abroad.
Written by: Yao Run
Edited by: Liu Jinyu