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ECNU has established friendly and cooperative relations with 6 universities and institutions in South America, including Candido Mendes University, Unisinos (Universidade do Vale do Rio dos Sinos), and Cearense Foundation of Support for Scientific and Technological Development (FUNCAP), and EAN (Escuela de Administración de Negocios) University and Universidad del Rosario in Colombia, and the University of Santo Tomás in Chile.
The University of Santo Tomás is the first sister school of ECNU in South America. A cooperation agreement was officially signed between ECNU and University of Santo Tomas in December 2010. The two universities signed an agreement to build a joint research centerin April 2015. Scholars from the two universities have carried out cooperative research and mutual visits in the fields of estuary and coast, environmental research, social development, and educational technology. As Chile features a special geographical location and abundant natural resources, multi-field cooperation has been fostered by the State Key Laboratory of Estuarine and Coastal Research of ECNU since the two universities began to cooperate. Moreover, the two universities signed an agreement of jointly cultivating PhDs in the field of estuary and coast and environment in 2018. They also agreed to carry out exchange programs for undergraduates majoring in Spanish.
In addition, ECNU has established an inter-school relationship with the Candido Mendes University in Brazil. Professor Enrique Larreta, Director of the Institute of Multiculturalism of the University, is currently a professor at the Latin American Cultural Research Center of ECNU. ECNU has signed a cooperation agreement with the Cearense Foundation of Support for Scientific and Technological Development (FUNCAP) in the field of estuary and coasts, jointly applying for projects of the China Scholarship Council. Additionally, ECNU has signed a memorandum of cooperation with EAN (Escuela de Administración de Negocios) University and Universidad del Rosario to promote the exchanges of students majoring in Spanish and advance the study of history and culture.