"Journal of American Chemical Society" publishes the research progress of Prof. Cheng Yiyun's team.
PAMAM dendrimers were widely used as nonviral gene carriers. PAMAM dendrimer-based products such as Superfect and Priofect were already commercially available gene transfection reagents. However, these products are based on high generation dendrimers with high cost and serious cytotoxicity. Prof. Cheng and his team first synthesized high efficient gene carriers using disulfide cross-linked low generation (generation 2, G2) PAMAM dendrimers. And their study demonstrated the PAMAM dendrimers has much improved gene transfection efficacy, low cytotoxicity and low cost, and can be efficient alternatives to high generation PAMAM dendrimers in gene delivery.
The research progress of Prof. Cheng’s team was published on Journal of American Chemical Society and won a patent. Experts say the high efficient gene carriers created by Prof.Cheng’s team has a very good commercial application prospect due to its easy operated method.
"Chemical Reviews" publishes Prof. Cheng and his team's progress in research of nuclear magnetic resonance (NUM) insights into dendrimer-based host-guest systems.
With his research interests focusing on the biomedical applications of dendrimers and other dendritic polymers, Prof.Cheng has made much original research progress in this field and has published more than 20 articles in peer-reviewed academic journals including Nature Materials, Chemical Society Reviews, and Journal of the American Chemical Society since he became a full professor of ECNU’s School of Life Sciences in 2010.
Written by: Liu Jinyu
